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Manifestări stiinţifice şi articole publicate
Mese rotunde:
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"Probleme ale terapiei cu antibiotice"
Temele propuse pentru dezbatere la Masă Rotundă "Probleme ale terapiei cu antibiotice" au fost:
 Antibioterapia şi riscul afectării renale:
- nefrotoxicitatea
- nefritele interstiţiale
- urolitiază
Consecinţe ale interacţiunii agenţilor antimicrobieni.
Rezistenţa bacteriană la antibiotice: cauze, mecanisme de apariţie.
Colita pseudomembranoasă - reacţie adversă a antibioticelor.
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"Artrita reumatoidă - Tendinţe terapeutice moderne"
Temele dezbătute la această manifestare au fost:
Principii de diagnostic în poliartrita reumatoidă - Conf. Dr. Simona Rednic - Catedra Medicală II - Reumatologie, Facultatea de Medicină
Principii de tratament în poliartrita reumatoidă - Prof. Dr. H.D. Bolosiu, Catedra Medicală II - Reumatologie
Clase de medicamente utilizate în poliartrita reumatoidă - Prof. Dr. Ana Mureşan - Catedra de chimie terapeutică, Facultatea de Farmacie.
Anticorpi monoclonali. Actualităţi în obţinerea şi utilizarea formelor farmaceutice - Asistent univ. Codruta Maier, Şef lucrări Dr. Cristina Iuga, Prof. Dr. Marius Bojiţă - Catedra de Analiza Medicamentului, Facultatea de Farmacie.
Anticitokine utilizate în poliartrita reumatoidă - Conf. Dr. Cristina Mogoşan - Catedra de Farmacologie, Facultatea de Farmacie.
Organizatorii acestei manifestări au fost: Centrul de informare asupra medicamentului, Facultatea de Farmacie, Catedra Medicală II - Reumatologie, din cadrul Universităţii de Medicină şi Farmacie "Iuliu Haţieganu" Cluj-Napoca; la masa rotundă cu tema Poliartrita reumatoidă - Tendinţe terapeutice moderne au participat medici din clinicile din Cluj-Napoca, farmacişti care activează în farmaciile spitalelor universitare şi în farmaciile publice, cadre didactice din UMF Iuliu-Haţieganu, Cluj-Napoca.
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Lucrări publicate in extenso:
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Acute renal failure as a consequence of perindopril and ketoprofen therapy.
Clujul Medical 2011; Vol 84,3:436-439. Camelia Denisa Bucsa, Irina Cazacu, Andrei
Achimas-Cadariu, Andreea Maria Farcas, Marius Traian Bojita.
asd
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Establishing an Adverse Drug Reactions Database in Romania: Practical Value.
Appl Med
Inform 2011; 28(2): 1-8. Farcas A, Chiorean T, Leucuta DL, Chereches R,
Bojita M.
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Siguranta medicatiei OTC in sarcina. Uneori o dilema
Clujul Medical, 2011; Vol. 84, Nr.3: 348-354. Irina Cazacu, Andreea Farcas, Cristina Mogosan, Marius Bojita
Rezumat
Medicamentele OTC sunt medicamentele ce pot fi eliberate fără prescripţie medicală. Datorită faptului că o multitudine de medicamente sunt disponibile OTC fiind considerate sigure, femeile însărcinate le utilzează din ce în ce mai mult fără un consult medical prealabil şi fără să cunoască riscurile pe care le pot avea asupra lor şi asupra fetuşilor. Disponibilitatea acestor produse OTC şi publicitatea încurajeazăconsumul de medicamente şi automedicaţia, oferind pacientului control absolut asupra simptomatologiei. S-a observat o creştere considerabilă a consumului de medicamente în timpul sarcinii, cele mai utilizate medicamente OTC fiind: analgezice, antipiretice, decongestionante, antihistaminice, antitusive şi expectorante, antiacide, antidiareice şi laxative. Marea majoritate a produselor OTC nu au un profil al siguranţei bine stabilit în sarcină. În timp ce unele medicamente OTC pot fi considerate sigure în urma datelor obţinute din utilizarea pe scară largă la gravide, altele au demonstrat a avea potenţial teratogenic sau au recomandări clare de a nu fi utilizate în prima perioadă sau în ultima perioadă a sarcinii. Înainte de utilizarea oricărui medicament în sarcină trebuie stabilit raportul beneficiu-risc, iar beneficiile tratamentului pentru mamă trebuie să depăşească întotdeauna riscurile pe care le are medicamentul asupra fătului.
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Adverse drug reactions detected by stimulated spontaneous reporting in an internal medicine department in Romania.
Eur J Int Med 2010; (21): 453-457 Farcas A, Sinpetrean A, Mogosan C, Palage M, Vostinaru O, Bojita M, Dumitrascu D
Abstract
Background: It is generally recognized that adverse drug reactions (ADRs) represent a major concern of health systems in terms of early recognition, proper management and prevention. The aim of this study was to identify the most frequent ADRs recognized by the attending physicians, study their nature and target these ADRs in order to take future preventive measures.
Methods: A prospective study was conducted over a 12-months period in an internal medicine department using stimulated spontaneous reporting for identifying ADRs. All ADRs reported by physicians were followed up to the patient’s discharge and evaluated by an independent group of pharmacologists. Causality, severity and preventability were assessed.
Results: Of the 1854 admissions, 112 ADRs in 94 patients (5.07%) were validated from the total of 118 ADRs reported. The overall incidence of serious ADRs in the hospitalized patients was 4.7%. According to the MedDRA classification, the most frequent ADRs affected the gastrointestinal system, followed by metabolic and vascular systems. The drugs most frequently involved were cardiovascular agents, anticoagulants and NSAIDs. Drug interactions were responsible for 25.9% of ADRs. According to the selected preventability scale, 40.18% ADRs were classified as ‘potentially preventable’ and 9.82% ‘definitely preventable’. Most of the ADRs were ‘type A’ reactions and as such could have been avoided simply by adjusting the doses or by avoiding drug interactions.
Conclusions: Serious ADRs in hospitalized patients are common and often preventable. Preventing strategies should target drug prescription. Adequate training regarding pharmacology and optimization of drug therapy might help reduce ADRs’ morbidity and mortality.
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Monitoring adverse reactions of the Cantgrip® vaccine.
FARMACIA 2010 –in print. Cristina Pop, Andreea Maria Farcas, Daniel-Corneliu Leucuta, Camelia Bucsa, Dana Faraian, Dan Razvan Florea, Doina Tatulescu, Marius Traian Bojita.
Abstract
Post-marketing vaccine safety monitoring is an important component of all vaccination programs. Early detection and quick response to adverse events following immunization can lessen their negative impact on health and on immunization programs themselves. For this reason, the current non-interventional, prospective study developed a method of further evaluating the safety of the A(H1N1) (Cantgrip®) vaccine used in Romania. 371 questionnaires were distributed to the health-care professionals at the moment of the immunization, 309 subjects returned the questionnaires in two weeks’ time. The most common injection-site reaction was pain (48.5%). Other local adverse reactions were redness, irritation and induration. The most common systemic adverse reactions reported were muscle ache (8.7%), chills (2.9%) and hyperhidrosis (1.9%). Fatigue (12.9%) was the most frequent neurological reaction reported. Most of the reported adverse reactions following immunization were mild-to-moderate. No life-threatening or adverse events of special interest were reported. The results of our study showed that, for an initial follow up of the studied group of subjects, Cantgrip® proved to be a safe vaccine.
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Patients reporting of suspected adverse reactions to antidepressants – a pilot methodological study.
FARMACIA, 2010; Vol 58, No 3: 255-264. Andreea Maria Farcas, Camelia Farah, Marius Traian Bojita.
Abstract
The benefits and the disadvantages of patient reporting have been much debated in the last years. In spite of being considered ‘anecdotal’, patient reporting had overcome at last the prejudices among regulators and it is now allowed in many Western countries. Moreover, studies have demonstrated that patient reporting is a useful tool of collecting experiences and information about what is a ‘tolerable’ adverse effect, but also about the daily use of medicines.
The current study aims to develop a systematic method that enables patients to report experienced adverse events that they think are due to their medication, using questionnaires returned in prepaid envelopes. Antidepressants agents were the drugs chosen for this pilot. We also wanted to determine the feasibility of a community pharmacy-based system to inform the patients about the possibility to report adverse events.
Patients in our study were willing to report adverse events. The patients proved to be capable of identifying and providing a clear description of their experiences that were due to antidepressant use. Antidepressant adverse effects represent a burden for the patients, being probably underestimated by the healthcare professionals.
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Adverse drug reactions in clinical practice. Causality assessment of a drug-induced pancreatitis case.
J Gastrointestin Liver Dis 2009; 18 (3): 353-358. Farcaş A, Bojiţă M.
Abstract
Modern therapy has changed the way diseases are controlled and has brought significant benefits to life. In spite of all the benefits, adverse drug reactions are a common, often preventable, cause of illness, disability and even death. Besides the intrinsic danger associated with the drug, patients might have a particular, unpredictable hypersensitivity to certain drugs, which requires careful monitoring.
Different studies have showed that adverse drug reactions related hospital admissions comprise up to 10% of the total number of hospitalizations. Adverse drug reactions can be difficult and sometimes impossible to distinguish from the patients’ disease as they act through the same physiological and pathological pathways. Unrecognized adverse drug reactions inflict health damage, hospital costs and may lead to prolonged hospitalization.
The purpose of this paper is to review and clarify some specific terminology and to assess the likelihood that a suspected adverse drug reaction is actually due to a medicine, by outlining the information needed for recognizing an adverse drug reaction and the steps of causality assessment of a theoretical drug-induced pancreatitis case.
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Physicians’ attitude towards voluntary reporting of adverse drug reactions.
FARMACIA, 2008, Vol. LVI, 5: 563-570. Andreea Farcas, Corina Macavei, M. Bojiţă.
Abstract
Modern therapy has changed the way that the diseases are controlled and has brought significant benefits to life, as it reduced morbidity and mortality rates. In spite of all the benefits, adverse drug reactions (ADR) are a common, often preventable cause of illness, disability and even death, and they had become a major problem of the health system. The voluntary, spontaneous reporting system for suspected adverse drug reactions is the main method for detecting rare, unexpected side effects of the drugs. The usefulness of this method may be compromised if the reporting rate is low.
Our study was designed to assess the attitude of the physicians towards the adverse drug reactions reporting system and the factors that cause under-reporting.
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Drug Information Research Center – promoting the rational use of medicines from 2004.
Ann Acad Ro Sci 2010; 1(1):109-120. Bojita M, Farcas A, Macavei C, Farah C.
Abstract
Research and new medical knowledge in past decades had lead to uncommon increase of the quantitative and qualitative information on pharmacotherapy. There are new modern therapies and a vast number of drug products available on the market. It is not humanly possible to remember the vast information on drugs. There has also been a great explosion in the number of biomedical journals published each year. In this context, one of the most important prerequisites concerning the selection of drugs for rational pharmacotherapy is the availability and easy access to independent, objective, unbiased information about drugs.
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Patient education-A need for the rational use of antibiotics.
Farmacia 2007; Vol LV, 6: 613-622. Macavei C, Maier C, Bojiţă M.
Rezumat
Rezistenţa la antibiotice (AB) este o problemă care necesită eforturi susţinute din partea autorităţilor din sănătate precum şi colaborare între medici – farmacişti. Studiile efectuate au identificat şi au examinat cauzele care duc la utilizarea abuzivă a antibioticelor, inclusiv prescrierea iraţională sau presiunea exercitată de pacienţi asupra medicilor şi farmaciştilor.
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Lucrări publicate în rezumat:
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First results from an intensified monitoring system to estimate and characterize adverse drug reactions in a department of internal medicine.
Drug Saf 2009; 32 (10):886 AM Farcas, CD Farah, M Palage, C Mogosan, O Vostinaru, AC Achimas, MT Bojita.
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Doxycycline induced severe thrombocytopenia: a case report.
Drug Saf 2009; 32 (10): 886-7 AM Farcas, O Vostinaru, C Mogosan, M Palage, AC Achimas, MT Bojita.
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Ampicillin induced cutaneous vasculitis: a case report.
Fundamental & Clinical Pharmacology 2010; Vol 24 (1): 90-91. C Mogosan, O Vostinaru, M Palage, AM Farcas, L Ciumarnean, AC Achimas, MT Bojita.
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A Romanian Drug Information Center’s activities.
Drug Information Journal 2010; 44 (2):200-201. CD Farah, AM Farcas, C Macavei, MT Bojita.
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